You can find a number of safes with various kinds of loot within each mission. Its a good idea to unlock any safes you come across since you can find incredibly valuable items most of the time.
When opening safes, there are two things to keep in mind. Any combination you discover in the world/map itself (like behind a painting), that combination will always be the same, no matter how many times you play through a mission. Meanwhile, any combinations you find in writings (like documents) are randomized. This means they will be different each time you play through the mission and try to open the safe associated with it.
Below is a list of known safes in each mission, as well as the combinations to open them.
Dr. Galvani’s Office – After leaving Dunwall Tower, enter the building on the left through the open door and look for a labratory with a painting of Lady Boyle as well as the safe. The combination 451 is scrawled in the frame of the painting that can be seen once it is stolen.
- Contains: Silver Ingots, Pistol, Ammo
Overseer Building – On the third floor there is a there is a safe that contains a Rune. The combination is random on each playthrough, and hidden within the Seven Scriptures. In the adjoining room where two Overseers are working on a music box, look for a note that says to remember three scriptures in particular. Cross reference them with the book of the seven scriptures near the safe, and you will have the combination.
- Contains: Rune, 3 Silver Ingots, Raw Whalebone
Winslow Safe Company – Located near the end of the mission down the street from the Addermire Station, in the Winslow Safe Company. There is a large safe with a challenge for anyone to unlock it. The safe combination is random in each playthrough, and it can be found in the cash register by the front desk in a note.
- Contains: Bonecharm, 2 Silver Ingots, 1 Gold Ingot, Pistol, Ammo
Addermire Institute Lobby – Once inside the Addermire Institute, Blink or Far Reach up to the second floor where the power to the Wall of Light is, and follow the corridor into an abandoned wing where a murdered body is near a locked safe. The randomized combination is written on a note on the right side of the room.
- Contains: Combat Sleep Dart Blueprint, Silver Ingot, Copper Wire
Dr. Vasco’s Office – Dr. Vasco has an office at the far end of the Disease Treatment wing, and he carries the combination to the lock himself. You can find him in the same room as Dr. Hypatia – in the small corridor on the lower floor outside the main operating room. Speaking with him, he’ll tell you the combination, and he also carries it in a note.
- Contains: Vasco’s Journal, Vasco’s Lab Key
Alley Office – Find the open building down the alley from the map of the Aventa District and head up to a first floor office. A note by the safe reads that the combination is in “the usual place”, and looking to a nearby chalkboard reveals two numbers 4 and 7, with the middle number smudged out. Return to the safe and keep spinning the middle number until the safe unlocks.
- Contains: Book, two silver ingots, lucky salpherite
Black Market – A locked desk drawer within the black market. The combination to unlock it is 4-2-8.
EditThe Grand Palace